Circadian PM

Circadian PM - Pharmedico
Circadian PM - Pharmedico

Circadian PM

Available in: Capsule
Regular price $59.98
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Complete sleep management with neurotransmitter, cytokine, and histamine support*

The importance of healthy sleep for overall health and well-being cannot be overstated. Unfortunately, achieving quality sleep is a challenge for many people. Common biological contributors to poor sleep can include physical discomfort, stress, anxiety, high histamine levels, and low levels of sleep-promoting neurotransmitters, such as gamma-aminobutyric acid (GABA).[1]

A multifaceted approach is needed to support falling asleep faster, staying asleep longer, and achieving higher quality, more restful sleep. Circadian PM™ utilizes a blend of 10 ingredients, promoting multiple mechanisms of action to nurture healthy sleep.

Mechanisms of Action*

  • Calms the central nervous system and promotes sleep initiation by:
    • Increasing GABA, the primary inhibitory central nervous system neurotransmitter*
    • Decreasing breakdown of GABA and its binding capacity *
    • Stimulating GABA receptors*
  • Promotes undisrupted sleep by supporting healthy serotonin levels, leading to increased REM sleep*
  • Reduces wakefulness by supporting healthy histamine levels in the brain*
  • Supports a healthy response to anxiety, promoting better sleep*
  • Promotes normal cytokine function to soothe physical discomfort and support neural cytokine levels*

Circadian PM™ features PharmaGABA®, the natural form of GABA, made through a natural fermentation process.  This results in a superior form of GABA  vs other synthetic options. Synthetic forms of GABA are less bio-available, as their molecular size is too large to pass the blood-brain barrier. PharmaGABA® is easily absorbed and binds to GABA receptors in the peripheral nervous system, activating the parasympathetic nervous system. This activation of the parasympathetic nervous system by PharmaGABA® is measurable within 5 to 30 minutes after ingestion .*

The unique blend of herbs, nutrients, and amino acids make Circadian PM™ a must-have formulation for patients dealing with sleep challenges and those who want to improve the quality of their sleep utilizing natural methods.



Features Constituents/Actions Benefits*
CalmNight Blend™ Glycine, Valerian Extract (Valeriana officinalis) (root), CurcuWIN™ Turmeric Extract, Lemon Balm Extract (Melissa officinalis) (leaf), Magnolia Extract (Magnolia officinalis) (bark), 5 HTP (5-hydroxytryptophan), L-theanine, PharmaGABA® (gamma-aminobutyric acid) • Supports NREM Stage 1 for sleep initiation*
• Nurtures restfulness to help maintain length of time asleep*
• Promotes the transition between NREM Stages (1-3), preparing the brain and body for deeper, restorative sleep*
• Supports REM, the most important sleep state, allowing the body to repair and restore itself*
• Anxiolytic and calming ingredients support GABA levels, as well as serotonin – a precursor to the natural production of melatonin, an essential hormone for quality sleep*
• Promotes healthy mental and physical relaxation to reduce wakefulness and restlessness*
• Supports normal cytokine function to relax the central nervous system and support physical discomfort*
HistaCalm™ Black Cumin Extract (Nigella sativa) (seed), Stinging Nettle Extract (leaf) • Promotes a healthy level of histamine to bind to its receptors by competitive inhibition*
• Reduces wakefulness by supporting healthy histamine levels in the brain*


 [1] The contributing factors to poor sleep experiences in according to the university students: A cross-sectional study Altun I et al. J Res Med Sci. 2012 Jun; 17(6): 557–561.


  • CalmNight™ Blend  |  2148mg
    • Glycine, Valerian Extract (Valeriana officinalis) (root), CurcuWIN™ Turmeric Extract, Lemon Balm Extract (Melissa officinalis) (leaf), Magnolia Extract (Magnolia officinalis) (bark), 5 HTP (5-hydroxytryptophan), L-theanine, PharmaGABA® (Gamma-aminobutyric acid)
  • HistaCalm™  |  126mg
    • Black Cumin Extract (Nigella sativa) (seed), Stinging Nettle Extract (leaf)

Other Ingredients: Vegetarian cellulose (capsule shell)

Manufactured without eggs, fish, crustacean shellfish, tree nuts, peanuts, wheat, corn and gluten. Produced in a facility that may process other ingredients containing these allergens.

Suggested Use: As a dietary supplement, take 3 capsules once daily before bed, or as directed by your healthcare professional.

Caution: Do not use while pregnant or nursing.

We use USPS or FEDEX to ship our orders depending on the weight, size and destination. If you provide a P.O. Box delivery address, we will use USPS to ship your order. A telephone number must be provided by you at checkout to provide to the shipping carrier.


Items can still be purchased, but may take longer to ship. If backordered items do not become available within 21 days, we will cancel those items and refund you for those products. If you have any questions on back-ordered products, please call our store at (941) 952-3959.

Shipping to International Shipments

Pharmedico Store does not ship to international locations at this time, except for Canada (subject to add'l shipping cost).  Please contact us before placing your order.

Shipment Timing
Orders placed by 2:00pm EST usually ship the same day, Monday through Friday. Shipments do not go out Saturday or Sunday, and all orders received over the weekend (after 2:00pm EST Friday – Sunday) will not be processed until the following Monday. Orders will not be processed and shipments will not be sent on company holidays. We maintain most product items available in our store inventory.

Occasionally, an item will be out of stock when an order is placed. In this case, the order will not ship until the back-ordered item are received in our store or we might drop-ship your product(s) directly from the manufacture if this is more than an extra day or two from the time you place your order, you will receive an e-mail from us detailing when the product(s) will be shipped and any other special situation regarding your order.

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