Sleep ON is a comprehensive formula created for patients experiencing occasional sleeplessness. Sleep ON promotes a healthy sleep cycle by naturally boosting levels of serotonin, GABA and melatonin.
- Formulated Specifically for Patients with Occasional Sleeplessness
- Promotes Calmness and Relaxation
- Supports Normal, Uninterrupted Sleep
- Provides Comprehensive Neurotransmitter Support
The synergistic ingredients in Sleep ON, including 5-HTP, PharmaGABA®, and taurine, boost levels of the neurotransmitters and hormones that promote relaxation prior to bedtime and increase the deep, restorative stages of sleep.
4 capsules taken one to two hours before bedtime or as recommended by your health care professional.
The sleep-regulating hormone melatonin requires the essential amino acid, L-tryptophan for conversion. A deficiency of L-tryptophan in the diet can lead to low serotonin and melatonin levels, which can contribute to sleep challenges. L-tryptophan is converted into the amino acid intermediate 5-hydroxytryptophan (5-HTP), which is then converted directly into serotonin, followed by melatonin conversion.
Gamma-amino butyric acid (GABA) is one of the major inhibitory neurotransmitters in the brain. GABA provides a calming effect and plays a direct role in activating the sleep cycle in the evening. Most commercially available forms of GABA utilize synthetically-produced GABA, manufactured from pyrrolidinone, a compound not allowed for use in Japan. Sleep ON includes a patented, naturally-sourced, non-synthetic form of GABA called PharmaGABA®. In a study utilizing 100 mg of PharmaGABA®, supplemented before bedtime, PharmaGABA® was shown to reduce sleep latency by 20%, while increasing time spent in a deep sleep by 20%.
Phosphatidylserine (PS) is a phospholipid found in high concentrations in the brain. Phosphatidylserine has been shown to play a role in regulating cortisol excretion. Elevated levels of cortisol throughout the night can contribute to frequent waking. When taken in the evening, PS can help reduce cortisol excretion from the body’s stress response system, the hypothalamic-pituitaryadrenal (HPA) axis, in order to promote a healthy sleep cycle.
Taurine is an amino acid that is found abundantly in the brain and has neuroprotective properties. Taurine promotes inhibitory neurotransmission by activating GABA receptors. Taurine also supports inhibitory neurotransmission by activating glycine receptors in the brain.
Calcium and magnesium are two minerals that play a major role in supporting a healthy sleep cycle. Magnesium (Mg) calms the nervous system and has been shown to play a role in the regulation of the HPA axis. Magnesium promotes relaxation by decreasing the activity of glutamate, the primary excitatory (stimulating) neurotransmitter in the brain. Calcium ions are a critical requirement in the synthesis of melatonin. The combination of 5-HTP and calcium in Sleep ON provides a significant and natural boost to melatonin levels, aiding in the conversion and activation of this crucial sleep hormone.
We use USPS or FEDEX to ship our orders depending on the weight, size and destination. If you provide a P.O. Box delivery address, we will use USPS to ship your order. A telephone number must be provided by you at checkout to provide to the shipping carrier.
Items can still be purchased, but may take longer to ship. If backordered items do not become available within 21 days, we will cancel those items and refund you for those products. If you have any questions on back-ordered products, please call our store at (941) 952-3959.
Shipping to International Shipments
Pharmedico Store does not ship to international locations at this time, except for Canada (subject to add'l shipping cost). Please contact us before placing your order.
Orders placed by 2:00pm EST usually ship the same day, Monday through Friday. Shipments do not go out Saturday or Sunday, and all orders received over the weekend (after 2:00pm EST Friday – Sunday) will not be processed until the following Monday. Orders will not be processed and shipments will not be sent on company holidays. We maintain most product items available in our store inventory.
Occasionally, an item will be out of stock when an order is placed. In this case, the order will not ship until the back-ordered item are received in our store or we might drop-ship your product(s) directly from the manufacture if this is more than an extra day or two from the time you place your order, you will receive an e-mail from us detailing when the product(s) will be shipped and any other special situation regarding your order.