- Supports Restorative Sleep
- Helps Induce Relaxation
- Supports Positive Mood
Busy and stressful lifestyles can cause sleep patterns to become disrupted, leading to over-stimulation and restlessness. Gamma-aminobutyric acid (GABA) is the brain’s primary neurotransmitter which helps to counteract stress by promoting a sense of relaxation. In the evening, GABA activity should increase in the brain, triggering the sleep cycle. The ingredients in Calm ON work in synergy to support GABA activity and allow for optimal relaxation.
Valerian root extract is perhaps the most studied botanical for inducing sleep. Valerenic acid, an active component in valerian root, has spasmolytic or muscle relaxant properties. It has been found to both inhibit the reuptake of and stimulate the release of GABA in the central nervous system (CNS). In addition, other components within valerian have been found to bind to GABA receptors. Randomized trials consistently show significant benefits to supplementing valerian over placebo. One randomized, double-blind, placebo-controlled trial comparing 600 mg/day of valerian extract given with another therapy for six weeks showed valerian root extract to be equally effective in supporting sleeplessness as a traditional approach.
The aerial portions of passionflower are best known for their historic use as a relaxing and calming herb. Numerous flavonoid components function as active ingredients by binding to the GABA receptor. Passionflower extract has compared favorably with other therapies with similar mechanisms of easing feelings of overstimulation and scattered thoughts, with fewer side effects. A randomized, placebo-controlled trial of 60 people, aged 25-55 years and scheduled for spinal anesthesia, showed those given passionflower experienced a greater sense of calmness before being given anesthesia. Passionflower has also been shown to offer sleep benefits for adults with fluctuations in sleep quality.
L-theanine is an amino acid found in green tea, and is considered a relaxant (although not a sedative) when used alone. The Food and Drug Administration has approved several health claims for L-theanine including: stress reduction, relaxation without drowsiness, decreased nervousness from common fatigue, and reduced nervous irritability. L-theanine has been shown to significantly increase alpha brain wave activity which correlates with a perceived state of relaxation.
Wild jujube seed has been historically used in traditional Chinese medicine as a sedative herb. It has been shown to reduce stress, conserve energy and promote sleep. It is useful for those with symptoms of nervous exhaustion, fatigue, irritability and the inability to sleep (Note: Most research on the active components [jujubosides A and B] for sedative and CNS function has been performed in China and are written in Chinese).
The hops plant, Humulus lupulus, is a perennial climbing vine that has been used for centuries for its relaxing properties, among other health benefits. Only the female hops, which produce flowers known as strobiles, are used for medicinal purposes. The active ingredients in hops include a volatile oil, valerianic acid, tannins and flavonoids. European studies have examined the effects of hops in combination with other sleep-supporting botanicals. In a pilot study that included 30 subjects with mild-to-moderate sleep challenges, a preparation combining 500 mg of valerian extract with 120 mg hops was given to subjects 30 minutes before bedtime. The hops-valerian preparation was found to improve sleep quality by decreasing sleep latency and wake time throughout the night.
We use USPS or FEDEX to ship our orders depending on the weight, size and destination. If you provide a P.O. Box delivery address, we will use USPS to ship your order. A telephone number must be provided by you at checkout to provide to the shipping carrier.
Items can still be purchased, but may take longer to ship. If backordered items do not become available within 21 days, we will cancel those items and refund you for those products. If you have any questions on back-ordered products, please call our store at (941) 952-3959.
Shipping to International Shipments
Pharmedico Store does not ship to international locations at this time, except for Canada (subject to add'l shipping cost). Please contact us before placing your order.
Orders placed by 2:00pm EST usually ship the same day, Monday through Friday. Shipments do not go out Saturday or Sunday, and all orders received over the weekend (after 2:00pm EST Friday – Sunday) will not be processed until the following Monday. Orders will not be processed and shipments will not be sent on company holidays. We maintain most product items available in our store inventory.
Occasionally, an item will be out of stock when an order is placed. In this case, the order will not ship until the back-ordered item are received in our store or we might drop-ship your product(s) directly from the manufacture if this is more than an extra day or two from the time you place your order, you will receive an e-mail from us detailing when the product(s) will be shipped and any other special situation regarding your order.